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Article

Insufficient maintenance DNA methylation is associated with abnormal embryonic development

13 Mar 2012

Abstract excerpt

BACKGROUND: Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood. DNA methylation, which includes maintenance methylation and de novo methylation directed by DNA methyltransferases (DNMTs), is important for embryo development. Abnormal function of these DNMTs may have serious consequences for embryonic development. METHODS: To evaluate the possible...

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PMID: 22413869
DOI: 10.1186/1741-7015-10-26

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