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Article

Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway.

PLoS biology - 1 Jan 2012

Erental Ariel, Sharon Idith, Engelberg-Kulka Hanna

Abstract excerpt

In eukaryotes, the classical form of programmed cell death (PCD) is apoptosis, which has as its specific characteristics DNA fragmentation and membrane depolarization. In Escherichia coli a different PCD system has been reported. It is mediated by the toxin-antitoxin system module mazEF. The E. coli mazEF module is one of the most thoroughly studied toxin-antitoxin systems. mazF encodes a stable toxin, MazF, and...

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PMID: 22412352
DOI: 10.1371/journal.pbio.1001281
PMCID: PMC3295820

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