Article
A self-lysis pathway that enhances the virulence of a pathogenic bacterium.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2015
McFarland Kirsty A, Dolben Emily L, LeRoux Michele, Kambara Tracy K, Ramsey Kathryn M, Kirkpatrick Robin L, Mougous Joseph D, Hogan Deborah A, Dove Simon L
Abstract excerpt
In mammalian cells, programmed cell death (PCD) plays important roles in development, in the removal of damaged cells, and in fighting bacterial infections. Although widespread among multicellular organisms, there are relatively few documented instances of PCD in bacteria. Here we describe a potential PCD pathway in Pseudomonas aeruginosa that enhances the ability of the bacterium to cause disease in a lung...
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