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Episomal HIV-1 DNA and its relationship to other markers of HIV-1 persistence

30 Jan 2018

Abstract excerpt

Reverse transcription of HIV-1 results in the generation of a linear cDNA that serves as the precursor to the integrated provirus. Other classes of extrachromosomal viral cDNA molecules can be found in acutely infected cells including the 1-LTR and 2-LTR circles of viral DNA, also referred as episomal HIV-1 DNA. Circulating CD4 + T-cells of treatment-naïve individuals contain significant levels of unintegrated...

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PMID: 29378611
DOI: 10.1186/s12977-018-0398-1

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