Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of cancer-associated mutations in the PlexinB1 gene.

Molecular cancer - 9 Mar 2012

Zhou Chun, Wong Oscar Gee-Wan, Masters John R, Williamson Magali

Abstract excerpt

BACKGROUND: Semaphorins act as chemotactic cues for cell movement via their transmembrane receptors, plexins. Somatic missense mutations in the plexinB1 gene coupled with overexpression of the protein frequently occur in prostate tumours, indicating a role for plexinB1 in the pathogenesis of pros...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to p21-Activated Kinases
Share to Proto-Oncogene Proteins c-met

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to rac GTP-Binding Proteins

Share to Receptor, ErbB-2

Share to Receptors, Cell Surface

Share to rho GTP-Binding Proteins

Share to rhoA GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22404908
DOI: 10.1186/1476-4598-11-11
PMCID: PMC3317836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22404908-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of cancer-associated mutations in the PlexinB1 gene.PMID 22404908Read ↗

Function of mutant and wild-type plexinb1 in prostate cancer cells.Semantic proximity Read ↗

The metastasis-promoting P1597L mutation in PlexinB1 enhances Ras activity.Semantic proximity Read ↗

Plexin-B1 mutation drives prostate cancer metastasisSemantic proximity Read ↗

PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor.Semantic proximity Read ↗

Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling.Semantic proximity Read ↗

PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis.Semantic proximity Read ↗

Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis.Semantic proximity Read ↗

An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migrationSemantic proximity Read ↗

Interaction characteristics of Plexin-B1 with Rho family proteins.Semantic proximity Read ↗

Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.Semantic proximity Read ↗

Glomerular mesangial cell recruitment and function require the co-receptor neuropilin-1.Semantic proximity Read ↗

Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.