Article
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
Circulation. Cardiovascular genetics - 1 Apr 2012
Kristiansson Kati, Perola Markus, Tikkanen Emmi, Kettunen Johannes, Surakka Ida, Havulinna Aki S, Stancáková Alena, Barnes Chris, Widen Elisabeth, Kajantie Eero, Eriksson Johan G, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T, Hartikainen Anna-Liisa, Ruokonen Aimo, Pouta Anneli, Jula Antti, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Männistö Satu, Jousilahti Pekka, Bonnycastle Lori L, Järvelin Marjo-Riitta, Kuusisto Johanna, Collins Francis S, Laakso Markku, Hurles Matthew E, Palotie Aarno, Peltonen Leena, Ripatti Samuli, Salomaa Veikko
Abstract excerpt
BACKGROUND: Genome-wide association (GWA) studies have identified several susceptibility loci for metabolic syndrome (MetS) component traits, but have had variable success in identifying susceptibility loci to the syndrome as an entity. We conducted a GWA study on MetS and its component traits in 4 Finnish cohorts consisting of 2637 MetS cases and 7927 controls, both free of diabetes, and followed the top loci in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.