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Article

FCRL3 -169C/C genotype is associated with anti-citrullinated protein antibody-positive rheumatoid arthritis and with radiographic progression.

The Journal of rheumatology - 1 Nov 2011

Maehlen Marthe T, Nordang Gry B, Syversen Silje W, van der Heijde Désirée M, Kvien Tore K, Uhlig Till, Lie Benedicte A

Abstract excerpt

OBJECTIVE: Studies of Caucasian populations have shown conflicting results concerning the association between a promoter polymorphism -169T>C of the Fc receptor-like 3 (FCRL3) gene and rheumatoid arthritis (RA). It is unknown whether FCRL3 is associated with autoantibody status and disease severity. We investigated associations between FCRL3 -169T>C and autoantibody status and joint damage in patients with RA....

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Source

Identifiers

PMID: 21885492
DOI: 10.3899/jrheum.110489

Genes

FCRL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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FCRL3 -169C/C genotype is associated with anti-citrullinated protein antibody-positive rheumatoid arthritis and with radiographic progression.PMID 21885492Read ↗

FCRL3 gene polymorphisms as risk factors for rheumatoid arthritis.Semantic proximity Read ↗

An updated meta-analysis of the Fc receptor-like 3 -169T/C polymorphism and rheumatoid arthritis risk.Semantic proximity Read ↗

The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases.Semantic proximity Read ↗

Association between functional Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and susceptibility to seropositive rheumatoid arthritis in Asians: a meta-analysis.Semantic proximity Read ↗

FCRL3 gene polymorphisms contribute to the radiographic severity rather than susceptibility of rheumatoid arthritis.Semantic proximity Read ↗

FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians.Semantic proximity Read ↗

Fc receptor-like 3 -169 C/T polymorphism and RA susceptibility: a meta-analysis.Semantic proximity Read ↗

Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?Semantic proximity Read ↗

Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population.Semantic proximity Read ↗

A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.Semantic proximity Read ↗

Association of FCRL3 genotypes with susceptibility of Iranian patients to rheumatoid arthritis.Semantic proximity Read ↗

Fc receptor-like 3 gene polymorphisms confer susceptibility to rheumatoid arthritis in a Chinese population.Semantic proximity Read ↗

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