Histological and genetic evidence for a variant of superficial spreading melanoma composed predominantly of large nests.

doi:10.1038/modpathol.2012.35

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Article

Histological and genetic evidence for a variant of superficial spreading melanoma composed predominantly of large nests.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2012

Kutzner Heinz, Metzler Gisela, Argenyi Zsolt, Requena Luis, Palmedo Gabriele, Mentzel Thomas, Rütten Arno, Hantschke Markus, Paredes Bruno E, Schärer Leo, Hesse Benedikt, El-Shabrawi-Caelen Laila, Shabrawi-Caelen Leila El, Fried Isabella, Kerl Helmut, Lorenzo Cerroni, Murali Rajmohan, Wiesner Thomas

Abstract excerpt

Cutaneous melanomas are characterized by a range of histological appearances, and several morphological variants have been described. In this study, we report a variant of superficial spreading melanoma that is characterized by large, irregular junctional melanocytic nests. The junctional nests varied in shape and size, showed focal tendency to confluence, and were often surrounded by a cuff of epidermal...

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PMID: 22388759
DOI: 10.1038/modpathol.2012.35

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