A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.

doi:10.1038/ng.1109

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Article

A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.

Nature genetics - 4 Mar 2012

Tanikawa Chizu, Urabe Yuji, Matsuo Keitaro, Kubo Michiaki, Takahashi Atsushi, Ito Hidemi, Tajima Kazuo, Kamatani Naoyuki, Nakamura Yusuke, Matsuda Koichi

Abstract excerpt

Through a genome-wide association analysis with a total of 7,035 individuals with duodenal ulcer and 25,323 controls from Japan, we identified two susceptibility loci at the PSCA gene (encoding prostate stem cell antigen) at 8q24 and at the ABO blood group locus at 9q34. The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10(-33)) in a...

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PMID: 22387998
DOI: 10.1038/ng.1109

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ABO
PSCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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