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Article

LEM-3 - A LEM domain containing nuclease involved in the DNA damage response in C. elegans.

PloS one - 1 Jan 2012

Dittrich Christina M, Kratz Katja, Sendoel Ataman, Gruenbaum Yosef, Jiricny Josef, Hengartner Michael O

Abstract excerpt

The small nematode Caenorhabditis elegans displays a spectrum of DNA damage responses similar to humans. In order to identify new DNA damage response genes, we isolated in a forward genetic screen 14 new mutations conferring hypersensitivity to ionizing radiation. We present here our characterization of lem-3, one of the genes identified in this screen. LEM-3 contains a LEM domain and a GIY nuclease domain. We...

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Identifiers

PMID: 22383942
DOI: 10.1371/journal.pone.0024555
PMCID: PMC3285610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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