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Article

Cell Lineage Analysis of the Mammalian Female Germline

23 Feb 2012

Abstract excerpt

Fundamental aspects of embryonic and post-natal development, including maintenance of the mammalian female germline, are largely unknown. Here we employ a retrospective, phylogenetic-based method for reconstructing cell lineage trees utilizing somatic mutations accumulated in microsatellites, to study female germline dynamics in mice. Reconstructed cell lineage trees can be used to estimate lineage relationships...

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PMID: 22383887
DOI: 10.1371/journal.pgen.1002477

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