Effective quantitative real-time polymerase chain reaction analysis of the parkin gene (PARK2) exon 1–12 dosage

Abstract excerpt

BACKGROUND: One of the causes of Parkinson's disease is mutations in the PARK2 gene. Deletions and duplications of single exons or exon groups account for a large proportion of the gene mutations. Direct detection of these mutations can be used for the diagnosis of Parkinson's disease. METHODS: To detect these mutations, we developed an effective technique based on the real-time TaqMan PCR system, which allows us...

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