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Article

Protective Gene Expression Changes Elicited by an Inherited Defect in Photoreceptor Structure

20 Feb 2012

Abstract excerpt

Inherited defects in retinal photoreceptor structure impair visual transduction, disrupt relationship with the retinal pigment epithelium (RPE), and compromise cell viability. A variety of progressive retinal degenerative diseases can result, and knowledge of disease etiology remains incomplete. To investigate pathogenic mechanisms in such instances, we have characterized rod photoreceptor and retinal gene...

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PMID: 22363631
DOI: 10.1371/journal.pone.0031371

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