Article
Simultaneous detection of Hb constant spring (α142, TAA>CAA, α2) and the α2 IVS-I donor site (-TGAGG) deletion by a simple polymerase chain reaction-based method in Iran.
Hemoglobin - 1 Jan 2012
Akhavan-Niaki Haleh, Banihashemi Ali, Mostafazadeh Amrollah, Kholghi Oskooei Vahid, Azizi Mandana, Youssefi Kamangar Reza, Elmi Maryam Mitra
Abstract excerpt
Hb Constant Spring (Hb CS, codon 142, TAA>CAA, α2) (HBA2:c.427T>C) and α2 IVS-I donor site (GAGGTGAGG>GAGG - - - - -) (HBA2:c.95+2_95+6delTGAGG) are nondeletional α-thalassemia (α-thal) mutations found all over the world. Identification of α-thal genotypes in at-risk couples for severe anemia or in highly heterogeneous populations requires rapid, accurate and cost-effective genotyping methods. In this study, a...
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