Article
Screening for Hb Constant Spring in the Guangdong Province, South China, using the Sebia capillary electrophoresis system.
Hemoglobin - 1 Jan 2011
Liao Can, Zhou Jian-Ying, Xie Xing-Mei, Li Dong-Zhi
Abstract excerpt
Hb Constant Spring [Hb CS; α142, Term→Gln (TAA>CAA in α2)] is a nondeletional α-thalassemia (α-thal) defect difficult to detect on conventional electrophoresis because of its small amount in heterozygotes. We have found that individuals with an Hb CS trait could efficiently be detected using the Sebia capillarys 2 system. In the present study, we have confirmed this method in a cohort of 23,842 individuals from...
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