Article
Hb Constant Spring [alpha 142, Term-->Gln (TAA>CAA in alpha2)] in the alpha-thalassemia of anemic patients in Myanmar.
Hemoglobin - 1 Jan 2008
Ne-Win, Harano Keiko, Harano Teruo, Kyaw-Shwe, Aye-Aye-Myint, Khin-Thander-Aye, Okada Shigeru
Abstract excerpt
Hb Constant Spring (Hb CS), the gene (alpha(CS)) of which arises from a point mutation in the termination codon of the alpha2-globin gene, is the most prevalent variety of nondeletional alpha-thalassemia (alpha-thal) in Asian populations. It is a major cause of Hb H disease in compound heterozygotes who have Hb CS combined with a duplicated alpha gene deletion (--/alpha(CS)alpha), and it tends to be more severe...
Topics
- Gene Deletion
- Genotype
- Hemoglobins, Abnormal
- Humans
- Myanmar
- Phenotype
- alpha-Thalassemia