Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.

doi:10.1172/JCI59410

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Article

Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.

The Journal of clinical investigation - 1 Mar 2012

Froese Alexander, Breher Stephanie S, Waldeyer Christoph, Schindler Roland F R, Nikolaev Viacheslav O, Rinné Susanne, Wischmeyer Erhard, Schlueter Jan, Becher Jan, Simrick Subreena, Vauti Franz, Kuhtz Juliane, Meister Patrick, Kreissl Sonja, Torlopp Angela, Liebig Sonja K, Laakmann Sandra, Müller Thomas D, Neumann Joachim, Stieber Juliane, Ludwig Andreas, Maier Sebastian K, Decher Niels, Arnold Hans-Henning, Kirchhof Paulus, Fabritz Larissa, Brand Thomas

Abstract excerpt

Cardiac pacemaker cells create rhythmic pulses that control heart rate; pacemaker dysfunction is a prevalent disorder in the elderly, but little is known about the underlying molecular causes. Popeye domain containing (Popdc) genes encode membrane proteins with high expression levels in cardiac myocytes and specifically in the cardiac pacemaking and conduction system. Here, we report the phenotypic analysis of...

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PMID: 22354168
DOI: 10.1172/JCI59410
PMCID: PMC3287222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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