Fetal radiation exposure induces testicular cancer in genetically susceptible mice.

doi:10.1371/journal.pone.0032064

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Article

Fetal radiation exposure induces testicular cancer in genetically susceptible mice.

PloS one - 1 Jan 2012

Shetty Gunapala, Comish Paul B, Weng Connie C Y, Matin Angabin, Meistrich Marvin L

Abstract excerpt

The prevalence of testicular germ cell tumors (TGCT), a common solid tissue malignancy in young men, has been annually increasing at an alarming rate of 3%. Since the majority of testicular cancers are derived from germ cells at the stage of transformation of primordial germ cell (PGC) into gonocytes, the increase has been attributed to maternal/fetal exposures to environmental factors. We examined the effects of...

Topics

Androgen Antagonists
Animals
Diethylstilbestrol
Estrogens, Non-Steroidal
Female
Fetus
Flutamide
Genetic Predisposition to Disease
Male
Maternal Exposure
Mice
Pregnancy
Prenatal Exposure Delayed Effects
Testicular Neoplasms

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PMID: 22348147
DOI: 10.1371/journal.pone.0032064
PMCID: PMC3278464

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