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Article

A Genetically Engineered Mouse Model of Malignant Testicular Germ Cell Tumors.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Lyndaker Amy M, Pierpont Timothy M, Loehr Amanda R, Weiss Robert S

Abstract excerpt

Testicular germ cell tumors (TGCTs) are among the most curable solid cancers and are typically highly responsive to conventional DNA-damaging chemotherapies, even in patients with metastatic disease. It has therefore been of great interest to understand the basis for the unique chemosensitivity of these cancers, which is linked to the DNA damage sensitivity of their cancer stem cells. TGCTs have been difficult to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32852763
DOI: 10.1007/978-1-0716-0860-9_11

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