Article
Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.
PloS one - 1 Jan 2012
Bol Sebastiaan M, Booiman Thijs, van Manen Daniëlle, Bunnik Evelien M, van Sighem Ard I, Sieberer Margit, Boeser-Nunnink Brigitte, de Wolf Frank, Schuitemaker Hanneke, Portegies Peter, Kootstra Neeltje A, van 't Wout Angélique B
Abstract excerpt
BACKGROUND: Infection with HIV-1 may result in severe cognitive and motor impairment, referred to as HIV-1-associated dementia (HAD). While its prevalence has dropped significantly in the era of combination antiretroviral therapy, milder neurocognitive disorders persist with a high prevalence. To identify additional therapeutic targets for treating HIV-associated neurocognitive disorders, several candidate gene...
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