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Article

Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance.

Journal of virology - 1 May 2012

Seibert Christopher W, Rahmat Saad, Krammer Florian, Palese Peter, Bouvier Nicole M

Abstract excerpt

The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing...

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Source

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Identifiers

PMID: 22345446
DOI: 10.1128/JVI.00151-12
PMCID: PMC3347392

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