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Article

A novel actin binding site of myosin required for effective muscle contraction.

Nature structural & molecular biology - 12 Feb 2012

Várkuti Boglárka H, Yang Zhenhui, Kintses Bálint, Erdélyi Péter, Bárdos-Nagy Irén, Kovács Attila L, Hári Péter, Kellermayer Miklós, Vellai Tibor, Málnási-Csizmadia András

Abstract excerpt

F-actin serves as a track for myosin's motor functions and activates its ATPase activity by several orders of magnitude, enabling actomyosin to produce effective force against load. Although actin activation is a ubiquitous property of all myosin isoforms, the molecular mechanism and physiological role of this activation are unclear. Here we describe a conserved actin-binding region of myosin named the...

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PMID: 22343723
DOI: 10.1038/nsmb.2216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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