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Article

Mycobacterium tuberculosis population structure determines the outcome of genetics-based second-line drug resistance testing.

Antimicrobial agents and chemotherapy - 1 May 2012

Streicher E M, Bergval I, Dheda K, Böttger E C, Gey van Pittius N C, Bosman M, Coetzee G, Anthony R M, van Helden P D, Victor T C, Warren R M

Abstract excerpt

The global emergence of multidrug-resistant tuberculosis has highlighted the need for the development of rapid tests to identify resistance to second-line antituberculosis drugs. Resistance to fluoroquinolones and aminoglycosides develops through nonsynonymous single nucleotide polymorphisms in the gyrA and gyrB genes and the rrs gene, respectively. Using DNA sequencing as the gold standard for the detection of...

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Identifiers

PMID: 22330913
DOI: 10.1128/AAC.05905-11
PMCID: PMC3346650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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