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Article

Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2011

Laarman Alexander J, Ruyken Maartje, Malone Cheryl L, van Strijp Jos A G, Horswill Alexander R, Rooijakkers Suzan H M

Abstract excerpt

Complement is one of the first host defense barriers against bacteria. Activated complement attracts neutrophils to the site of infection and opsonizes bacteria to facilitate phagocytosis. The human pathogen Staphylococcus aureus has successfully developed ways to evade the complement system, for example by secretion of specific complement inhibitors. However, the influence of S. aureus proteases on the host...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21502375
DOI: 10.4049/jimmunol.1002948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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