Article
Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor.
European journal of haematology - 1 Jul 2012
Georgin-Lavialle Sophie, Lhermitte Ludovic, Suarez Felipe, Yang Ying, Letard Sébastien, Hanssens Katia, Feger Frédéric, Renand Amédée, Brouze Chantal, Canioni Danielle, Asnafi Vahid, Chandesris Marie-Olivia, Aouba Achille, Gineste Paul, Macintyre Elizabeth, Mansfield Colin D, Moussy Alain, Lepelletier Yves, Dubreuil Patrice, Hermine Olivier
Abstract excerpt
OBJECTIVE: Most patients with systemic mastocytosis bear mutations in the tyrosine kinase receptor gene c-Kit. Limited treatment options exist for mast cell leukemia, a rare form of systemic mastocytosis associated with a dire prognosis. Our aim was to investigate c-Kit mutations associated with mast cell leukemia and find new treatment for this severe form of mastocytosis. PATIENT AND METHODS: We describe here a...
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