Article
IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.
Human molecular genetics - 1 May 2012
Nguyen Hai Ha, Takata Ryo, Akamatsu Shusuke, Shigemizu Daichi, Tsunoda Tatsuhiko, Furihata Mutsuo, Takahashi Atsushi, Kubo Michiaki, Kamatani Naoyuki, Ogawa Osamu, Fujioka Tomoaki, Nakamura Yusuke, Nakagawa Hidewaki
Abstract excerpt
Recent genome-wide association studies (GWAS) identified a number of prostate cancer (PC) susceptibility loci, but most of their functional significances are not elucidated. Through our previous GWAS for PC in a Japanese population and subsequent resequencing and fine mapping, we here identified that IRX4 (Iroquois homeobox 4), coding Iroquois homeobox 4, is a causative gene of the PC susceptibility locus...
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