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Article

Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection.

Journal of virology - 1 Apr 2012

Van Stry Melanie, Oguin Thomas H, Cheloufi Sihem, Vogel Peter, Watanabe Makiko, Pillai Meenu R, Dash Pradyot, Thomas Paul G, Hannon Gregory J, Bix Mark

Abstract excerpt

RNA interference (RNAi) is a critical component of many cellular antiviral responses in plants, invertebrates, and mammals. However, its in vivo role in host protection from the negative-sense RNA virus influenza virus type A (flu) is unclear. Here we have examined the role of RNAi in host defense to flu by analyzing Argonaute 1 and 3 double-knockout mice deficient in components of the RNA-induced silencing...

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Source

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Identifiers

PMID: 22318144
DOI: 10.1128/JVI.05303-11
PMCID: PMC3318639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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