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Article

Streptomyces nodosus host strains optimized for polyene glycosylation engineering.

Bioscience, biotechnology, and biochemistry - 1 Jan 2012

Stephens Niamh, Rawlings Bernard, Caffrey Patrick

Abstract excerpt

The AmphDI glycosyltransferase transfers a mycosaminyl sugar residue from GDP onto 8-deoxyamphoteronolide B, the aglycone of the antifungal amphotericin B. In this study the amphDI gene was inactivated in Streptomyces nodosus strains lacking the AmphN cytochrome P450. The new mutants produced 8-deoxy-16-methyl-16-descarboxyl amphoteronolides in high yield. These strains and aglycones should prove valuable for in...

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Identifiers

PMID: 22313766
DOI: 10.1271/bbb.110673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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