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Article

Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.

The Journal of biological chemistry - 14 Oct 2005

Carmody Maria, Murphy Barry, Byrne Barry, Power Patrick, Rai Dilip, Rawlings Bernard, Caffrey Patrick

Abstract excerpt

Amphotericin B is a medically important antifungal antibiotic that is also active against human immunodeficiency virus, Leishmania parasites, and prion diseases. The therapeutic use of amphotericin B is restricted by severe side effects that can be moderated by liposomal formulation or structural alteration. Chemical modification has shown that suppression of charge on the exocyclic carboxyl group of amphotericin...

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PMID: 16079135
DOI: 10.1074/jbc.M506689200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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