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Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol

28 Aug 2023

Abstract excerpt

Prenatal paracetamol exposure has been associated with neurodevelopmental outcomes in childhood. Pharmacoepigenetic studies show differences in cord blood DNA methylation between unexposed and paracetamol-exposed neonates, however, causality and impact of long-term prenatal paracetamol exposure on brain development remain unclear. Using a multi-omics approach, we investigated the effects of paracetamol on an in...

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PMID: 37731623
DOI: 10.1016/j.isci.2023.107755

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