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Article

Modified PNA-PCR method: a convenient and accurate method to screen plasma KRAS mutations of cancer patients.

Cancer biology & therapy - 1 Mar 2012

Yu Shaorong, Wu Jianzhong, Xu Shu, Tan Guolei, Liu Baorui, Feng Jifeng

Abstract excerpt

KRAS mutations are proved to confer dramatic resistance to EGFR target therapy of cancer patients. The aim of this study was to establish a convenient and accurate method to screen plasma KRAS mutations of cancer patients since tumor specimens were not always available in clinical practice. A modified PNA-PCR method was established and evaluated in plasma of 19 pancreatic cancer patients. Our results showed that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22310974
DOI: 10.4161/cbt.19075

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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