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Article

Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss.

PloS one - 28 Feb 2011

Garaulet Marta, Sánchez-Moreno Carmen, Smith Caren E, Lee Yu-Chi, Nicolás Francisco, Ordovás Jose M

Abstract excerpt

BACKGROUND: Circadian Locomotor Output Cycles Kaput (CLOCK), an essential element of the positive regulatory arm in the human biological clock, is involved in metabolic regulation. The aim was to investigate the behavioral (sleep duration, eating patterns and chronobiological characteristics) and hormonal (plasma ghrelin and leptin concentrations) factors which could explain the previously reported association...

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Identifiers

PMID: 21386998
DOI: 10.1371/journal.pone.0017435
PMCID: PMC3046145

Genes

CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss.PMID 21386998Read ↗

Association Between CLOCK 3111 T/C Polymorphism with Ghrelin, GLP-1, Food Timing, Sleep and Chronotype in Overweight and Obese Iranian AdultsSemantic proximity Read ↗

Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C.Semantic proximity Read ↗

SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity.Semantic proximity Read ↗

CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet.Semantic proximity Read ↗

Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position.Semantic proximity Read ↗

Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: association with higher body mass index.Semantic proximity Read ↗

Association between genetic variants of the clock gene and obesity and sleep duration.Semantic proximity Read ↗

Association of eating behaviour with clock gene polymorphism 3111 T > C in children based on nutritional status.Semantic proximity Read ↗

Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren.Semantic proximity Read ↗

Association between CLOCK gene polymorphisms with circadian rhythm, chrononutrition, dietary intake, and metabolic parameters in adolescents.Semantic proximity Read ↗

CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control.Semantic proximity Read ↗

Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project.Semantic proximity Read ↗

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