Article
Norovirus GII.4 and GII.7 capsid sequences undergo positive selection in chronically infected patients.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2012
Hoffmann Dieter, Hutzenthaler Martin, Seebach Judith, Panning Marcus, Umgelter Andreas, Menzel Helge, Protzer Ulrike, Metzler Dirk
Abstract excerpt
Norovirus has become an important cause for infectious gastroenteritis. Particularly genotype II.4 (GII.4) has been shown to spread rapidly and causes worldwide pandemics. Emerging new strains evade population immunity and lead to high norovirus prevalence. Chronic infections have been described recently and will become more prevalent with increasing numbers of immunocompromized patients. Here, we studied...
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