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Article

Expression of GIV/Girdin, a metastasis‐related protein, predicts patient survival in colon cancer

25 Oct 2010

Abstract excerpt

Metastasis accounts for the majority of cancer-related deaths. Accurate prediction of metastatic potential of tumors has been elusive, and the search for clinically useful markers continues. We previously reported that GIV/Girdin triggers tumor cell migration by virtue of a C-terminal guanine-nucleotide exchange factor motif that activates Gαi. Here we identify GIV as a metastasis-related protein whose...

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PMID: 20974669
DOI: 10.1096/fj.10-167304

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