Article
p95HER2 truncated form in resected non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2012
Cappuzzo Federico, Cho Yong Gon, Sacconi Andrea, Alì Greta, Siclari Olimpia, Incarbone Matteo, Destro Annarita, Terracciano Luigi, Fontanini Gabriella, Marchetti Antonio, Roncalli Massimo, Varella-Garcia Marileila
Abstract excerpt
INTRODUCTION: Recent studies suggested that p95HER2, the NH2-terminally truncated form of human epidermal growth factor receptor 2 (HER2), could confer resistance to monoclonal antibodies against HER2 (HER2-mab). The aim of this study was to investigate the role of p95HER2 according to HER2 gene copy number (GCN) and HER2 mutation in non-small cell lung cancer (NSCLC). METHODS: The study included 447 resected...
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