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Beyond Il-5: Metabolic Reprogramming and Stromal Support Are Prerequisite for Generation and Survival of Long-Lived Eosinophil.

Cells - 6 Apr 2021

Coden Mackenzie E, Walker Matthew T, Jeong Brian M, Connelly Andrew R, Nagasaka Reina, Berdnikovs Sergejs

Abstract excerpt

Eosinophils play surprisingly diverse roles in health and disease. Accordingly, we have now begun to appreciate the scope of the functional and phenotypic heterogeneity and plasticity of these cells. Along with tissue-recruited subsets during inflammation, there are tissue resident eosinophil phenotypes with potentially longer life spans and less dependency on IL-5 for survival. Current models to study murine...

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Identifiers

PMID: 33917349
DOI: 10.3390/cells10040815
PMCID: PMC8067430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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