Article
High-resolution genotyping of the endemic Salmonella Typhi population during a Vi (typhoid) vaccination trial in Kolkata.
PLoS neglected tropical diseases - 1 Jan 2012
Holt Kathryn E, Dutta Shanta, Manna Byomkesh, Bhattacharya Sujit K, Bhaduri Barnali, Pickard Derek J, Ochiai R Leon, Ali Mohammad, Clemens John D, Dougan Gordon
Abstract excerpt
BACKGROUND: Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), is a major health problem especially in developing countries. Vaccines against typhoid are commonly used by travelers but less so by residents of endemic areas. METHODOLOGY: We used single nucleotide polymorphism (SNP) typing to investigate the population structure of 372 S. Typhi isolated during a typhoid disease burden study and...
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