Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study.

doi:10.1016/S2666-5247(24)00047-8

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Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study.

The Lancet. Microbe - 1 Aug 2024

Dyson Zoe A, Ashton Philip M, Khanam Farhana, Chunga Chirambo Angeziwa, Shakya Mila, Meiring James E, Tonks Susan, Karkey Abhilasha, Msefula Chisomo, Clemens John D, Dunstan Sarah J, Baker Stephen, Dougan Gordon, Pitzer Virginia E, Basnyat Buddha, Qadri Firdausi, Heyderman Robert S, Gordon Melita A, Pollard Andrew J, Holt Kathryn E

Abstract excerpt

BACKGROUND: Enteric fever is a serious public health concern. The causative agents, Salmonella enterica serovars Typhi and Paratyphi A, frequently have antimicrobial resistance (AMR), leading to limited treatment options and poorer clinical outcomes. We investigated the genomic epidemiology, resistance mechanisms, and transmission dynamics of these pathogens at three urban sites in Africa and Asia. METHODS: S...

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PMID: 38996496
DOI: 10.1016/S2666-5247(24)00047-8
PMCID: PMC11300424

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