Article
T160A mutation-induced deglycosylation at site 158 in hemagglutinin is a critical determinant of the dual receptor binding properties of clade 2.3.4.4 H5NX subtype avian influenza viruses.
Veterinary microbiology - 1 Apr 2018
Gao Ruyi, Gu Min, Liu Kaituo, Li Qunhui, Li Juan, Shi Liwei, Li Xiuli, Wang Xiaoquan, Hu Jiao, Liu Xiaowen, Hu Shunlin, Chen Sujuan, Peng Daxin, Jiao Xinan, Liu Xiufan
Abstract excerpt
Most clade 2.3.4.4 H5NX subtype avian influenza viruses possess a T160A amino acid substitution in the hemagglutinin (HA) protein that has been shown to affect the receptor binding properties of a clade 2.3.4 H5N1 virus. However, the effect of this single site mutation on the HA backbone of clade 2.3.4.4 H5NX viruses remains unclear. In this study, two H5N6 field isolates possessing HA-160A with dual α-2,3 and...
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