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Article

VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing.

Genome research - 1 Mar 2012

Koboldt Daniel C, Zhang Qunyuan, Larson David E, Shen Dong, McLellan Michael D, Lin Ling, Miller Christopher A, Mardis Elaine R, Ding Li, Wilson Richard K

Abstract excerpt

Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and mutations across hundreds of tumors. Here we present an analysis tool, VarScan 2, for the detection of somatic mutations and copy number alterations (CNAs) in exome data from tumor-normal pairs. Unlike most current approaches, our algorithm reads data from both samples simultaneously;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22300766
DOI: 10.1101/gr.129684.111
PMCID: PMC3290792

Genes

CCNE1
MYC
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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