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Article

Suppression of Type I Collagen Expression by miR-29b via PI3K, Akt, and Sp1 Pathway in Human Tenon's Fibroblasts

2 Feb 2012

Abstract excerpt

PURPOSE: To evaluate the expression profile of microRNAs (miRNAs) and their roles in human Tenon's fibroblasts (HTFs), and to establish an miRNA-based gene-silencing method for antifibrosis in vitro. METHODS: The miRNA expression profile was analyzed by microarray using quiescent and transforming growth factor beta 1 (TGFβ1)-stimulated primary HTFs, respectively. Candidate miRNAs were identified by quantitative...

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PMID: 22297492
DOI: 10.1167/iovs.11-8670

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