Article
A review of the genetic background and tumour profiling in familial colorectal cancer.
Mutagenesis - 1 Mar 2012
van Wezel Tom, Middeldorp Anneke, Wijnen Juul T, Morreau Hans
Abstract excerpt
Inherited predisposition plays a role in 10-30% of colorectal cancer (CRC) cases. Of the large families with a clearly positive family history of CRC, ∼40% is not affected by known CRC syndromes. The existence of families with unexplained forms of inherited CRC--familial CRC--suggests the presenc...
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