Article
Retinoblastoma.
Seminars in diagnostic pathology - 1 May 1994
Lueder G T, Smith M E
Abstract excerpt
Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of...
Topics
- Child, Preschool
- Eye Neoplasms
- Genes, Retinoblastoma
- Humans
- Infant
- Mutation
- Neoplasms, Second Primary
- Retinoblastoma