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Article

Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells

9 Feb 2010

Abstract excerpt

The majority of human miRNA genes is transcribed by polymerase II and can be classified as class II genes similar to protein-coding genes. Whereas current research on miRNAs has focused on the physiological and pathological functions, the molecular mechanisms underlying their transcriptional regulation are largely unknown. We recently reported that lipopolysaccharide (LPS) alters mature miRNA expression profile...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
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PMID: 20144951
DOI: 10.1093/nar/gkq056

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