Article
Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4Δ53.
Veterinary research - 5 Mar 2015
Clawson Michael L, Redden Reid, Schuller Gennie, Heaton Michael P, Workman Aspen, Chitko-McKown Carol G, Smith Timothy P L, Leymaster Kreg A
Abstract excerpt
Small ruminant lentivirus (SRLV) infections of sheep are influenced by genetics on both the host and pathogen sides. Genetic variation in the ovine transmembrane 154 (TMEM154) gene associates with infection susceptibility, and distinct SRLV genetic subgroups infect sheep in association with their TMEM154 diplotypes. In this study, a novel SRLV subgroup was identified that naturally infected sheep with various...
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