Article
Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contacts.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Apr 2012
Cobat Aurélie, Barrera Luis F, Henao Hanna, Arbeláez Patricia, Abel Laurent, García Luis F, Schurr Erwin, Alcaïs Alexandre
Abstract excerpt
The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining ∼65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection.
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