Article
Microevolution in fimH gene of mucosa-associated Escherichia coli strains isolated from pediatric patients with inflammatory bowel disease.
Infection and immunity - 1 Apr 2012
Iebba Valerio, Conte Maria Pia, Lepanto Maria Stefania, Di Nardo Giovanni, Santangelo Floriana, Aloi Marina, Totino Valentina, Checchi Monica Proietti, Longhi Catia, Cucchiara Salvatore, Schippa Serena
Abstract excerpt
Several studies reported increased numbers of mucosa-associated Escherichia coli strains in patients with inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC). The majority of E. coli strains possess type 1 fimbriae, whose tip fibrillum protein, FimH, naturally undergoes amino acid replacements, an important process in the adaptation of commensal E. coli strains to...
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