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Article

Novel ADAMTS-13 mutations in an adult with delayed onset thrombotic thrombocytopenic purpura.

Journal of thrombosis and haemostasis : JTH - 1 Sept 2006

Tao Z, Anthony K, Peng Y, Choi H, Nolasco L, Rice L, Moake J L, Dong J-F

Abstract excerpt

BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is associated with congenital and acquired deficiency of ADAMTS-13, a metalloprotease that cleaves von Willebrand factor (VWF) and reduces its adhesive activity. Mutations throughout the ADAMTS13 gene have been identified in congenital TTP patients, most of whom have initial episodes during infancy or in early childhood. PATIENTS AND METHODS: We report the...

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Source

Identifiers

PMID: 16796708
DOI: 10.1111/j.1538-7836.2006.02098.x

Genes

VWF
ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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