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Article

Accumulation of endogenous LITAF in aggresomes.

PloS one - 1 Jan 2012

Eaton Heather E, Metcalf Julie, Lacerda Andressa Ferreira, Brunetti Craig R

Abstract excerpt

LITAF is a 161 amino acid cellular protein which includes a proline rich N-terminus and a conserved C-terminal domain known as the simple-like domain. Mutations in LITAF have been identified in Charcot-Marie tooth disease, a disease characterized by protein aggregates. Cells transfected with cell...

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Source

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Identifiers

PMID: 22276139
DOI: 10.1371/journal.pone.0030003
PMCID: PMC3261850

Genes

LITAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22276139-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 11 closest

Accumulation of endogenous LITAF in aggresomes.PMID 22276139Read ↗

Characterisation of LITAF, a protein associated with Charcot-Marie-Tooth disease type 1CSemantic proximity Read ↗

Mutations associated with Charcot–Marie–Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome–autophagy pathwaysSemantic proximity Read ↗

LITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria.Semantic proximity Read ↗

LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease.Semantic proximity Read ↗

LC3A-mediated autophagy elicits PERK-eIF2α-ATF4 axis activation and mitochondrial dysfunction: Exposing vulnerability in aggresome-positive cancer cellsSemantic proximity Read ↗

The LITAF/SIMPLE I92V sequence variant results in an earlier age of onset of CMT1A/HNPP diseases.Semantic proximity Read ↗

Exfoliation Syndrome: A Disease of Autophagy and LOXL1 ProteopathySemantic proximity Read ↗

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein.Semantic proximity Read ↗

SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.Semantic proximity Read ↗

The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.Semantic proximity Read ↗

C-terminally mutated tubby protein accumulates in aggresomes.Semantic proximity Read ↗

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