LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease.

Abstract excerpt

Missense mutations affecting the LITAF gene (also known as SIMPLE) lead to the dominantly inherited peripheral neuropathy Charcot-Marie-Tooth disease type 1C (CMT1C). In this study, we sought to determine the requirement of Litaf function in peripheral nerves, the only known affected tissue in CMT1C. We reasoned that this knowledge is a prerequisite for a thorough understanding of the underlying disease mechanism...

Topics

• Age Factors
• Animals
• Animals, Newborn
• Cell Movement
• Cells, Cultured
• DNA-Binding Proteins
• Disease Models, Animal
• Gene Expression Regulation, Developmental
• Macrophages
• Mice